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Casey T. Weaver, M.D.

Professor of Pathology

 

Phone: 975-5537

E-mail: weaver@path.uab.edu

 

 

 

Dr. Weaver received his B.S. (biochemistry) and M.D. from the University of Florida.  He then completed internsip and residency in pathology at Jewish and Barnes Hospitals, Washington University, St. Louis, followed by postdoctoral training in immunology in the Department of Pathology also at Washington University, St. Louis.  He was an Assistant Professor in the Department of Pathology at Washington University until joining the Department of Pathology faculty at UAB in 1992.

The broad research interest of Dr. Weaver’s laboratory concerns the mechanisms that control CD4+ T cell responses.  Major projects in his laboratory include the following: the development and characterization of transgenic and knock-in mouse models for tracking T cell fate during CD4+ T cell phenotype development (Saparov et al., Immunity 11:271, 1999; Hurez et al., J. Exp. Med., In Press); development and characterization of an antigen-specific model of inflammatory bowel disease (Iqbal et al., J. Exp. Med., 195:71-84, 2002); delineation of mechanisms controlling CD4 regulatory cell function (Kubo et al., manuscript in preparation); characterization of the molecular regulation of cytokine gene expression in effector T cells (Dzialo-Hatton et al., J. Immunol. 166:4534, 2001); and development of a transgenic model for adenoviral-mediated gene delivery into primary T cells (Hurez et al., BMC Immunol. 3:4, 2002).

Selected Publications

  1. Bucy, R.P., Panoskaltsis-Mortari, A., Huang, G.Q., Li, J., Karr, L., Ross, M., Russell, J.H., Murphy, K.M., and Weaver, C.T. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J. Exp. Med. 180:1251-1262, 1994.

  2. Bucy, R.P., Karr, L., Huang, G.Q., Li, J., Carte,r D., Honjo, K., Lemons, J.A., Murphy, K.M., and Weaver, C.T. Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development. Proc. Natl. Acad. Sci. U S A. 92:7565-7569, 1995.

  3. Saparov, A., Kraus, L.A., Cong, Y., Marwill, J., Xu, X.Y., Elson, C.O., and Weaver, C.T. Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second,endogenous TCR. Int. Immunol. 11:1253-1264, 1999.

  4. Saparov, A., Wagner, F.H., Zheng, R., Oliver, J.R., Maeda, H., Hockett, R.D., and Weaver, C.T. Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effectorfunction. Immunity. 11:271-280, 1999.

  5. Dzialo-Hatton, R., Milbrandt, J., Hockett, R.D. Jr., and Weaver, C.T. Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members. J. Immunol. 166:4534-4542, 2001.

  6. Elson, C.O., Cong, Y., Iqbal, N., and Weaver, C.T. Immuno-bacterial homeostasis in the gut: new insights into an old enigma. Semin. Immunol. 13:187-194, 2001. Review.

  7. Iqbal, N., Oliver, J.R., Wagner, F.H., Lazenby, A.S., Elson, C.O., and Weaver, C.T. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J. Exp. Med. 195:71-84, 2002.

  8. Hurez, V., Dzialo-Hatton, R., Oliver, J., Matthews, R.J., and Weaver, C.T. Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model. BMC Immunol. 3:4, 2002.

  9. Bullard, D.C., and Weaver, C.T. Cutting-edge technology: IV. Genomic engineering for studies of the gastrointestinal tract in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 283:G1232-1237, 2002. Review. 

  10. Hurez, V., Saparov, A., Tousson, A., Fuller, M.J., Kubo, T., Oliver, J., Weaver, B.T., and Weaver, C.T.  Restricted clonal expression of IL-2 by naïve T cells reflects differential dynamic interactions with dendritic cells. J. Exp. Med., 198:456-132, 2003.